The Ablatherm[JO1] ® HIFU and Focal One® are both medical devices used to treat localised prostate cancer with High Intensity Focused Ultrasound (HIFU). These two devices allow for non-invasive local treatment, in a single session, repeatable if necessary with few side effects. Focal One® is the latest and first device dedicated to focal therapy for prostate cancer. It allows images from diagnostic tools (MRI, biopsies) to be merged in order to target only the area of the prostate affected by cancer.